Rob Stein; NPR; Experts weigh medical advances in gene-editing with ethical dilemmas; NPR, March 6, 2023

Rob Stein; NPR; Experts weigh medical advances in gene-editing with ethical dilemmas

"Hundreds of scientists, doctors, bioethicists, patients, and others started gathering in London Monday for the Third International Summit on Human Genome Editing. The summit this week will debate and possibly issue recommendations about the thorny issues raised by powerful new gene-editing technologies.\

The last time the world's scientists gathered to debate the pros and cons of gene-editing — in Hong Kong in late 2018 — He Jiankui, a biophysicist and researcher at Southern University of Science and Technology in Shenzhen, China, shocked his audience with a bombshell announcement. He had created the first gene-edited babies, he told the crowd — twin girls born from embryos he had modified using the gene-editing technique CRISPR."

How to protect the first ‘CRISPR babies’ prompts ethical debate; Nature, February 25, 2022

Smriti Mallapaty, Nature; How to protect the first ‘CRISPR babies’ prompts ethical debate

"Two prominent bioethicists in China are calling on the government to set up a research centre dedicated to ensuring the well-being of the first children born with edited genomes. Scientists have welcomed the discussion, but many are concerned that the pair’s approach would lead to unnecessary surveillance of the children.

The proposal comes ahead of the possibly imminent release from prison of He Jiankui, the researcher who in 2018 shocked the world by announcing that he had created babies with altered genomes. He’s actions were widely condemned by scientists around the world, who called for a global moratorium on editing embryos destined for implantation. Several ethics committees have since concluded that the technology should not be used to make changes that can be passed on."

Once Science Fiction, Gene Editing Is Now a Looming Reality; The New York Times, July 22, 2020

Katie Hafner, The New York Times; Once Science Fiction, Gene Editing Is Now a Looming Reality

The prospect of erasing some disabilities and perceived deficiencies hovers at the margins of what people consider ethically acceptable.

"Professor Halley acknowledged the inherent tension between the huge benefits that gene-editing technology could bring in preventing serious diseases and disabilities for which there is no treatment, and what she calls the “potential risk of going down a road that feels uncomfortably close to eugenics.”

Less ethically freighted are therapies to cure serious diseases in people who are already living with them. “I think that there are opportunities to use gene-editing technologies to treat genetic diseases that don’t raise the societal implications of altering permanently patterns of human inheritance,” said Dr. Alex Marson, director of the Gladstone-UCSF Institute of Genomic Immunology in San Francisco."

What CRISPR-Baby Prison Sentences Mean for Research; Nature via Scientific American, Janaury 6, 2020

David Cyranoski, Nature via Scientific American; What CRISPR-Baby Prison Sentences Mean for Research

"A Chinese court has sentenced He Jiankui, the biophysicist who announced that he had created the world’s first gene-edited babies, to three years in prison for “illegal medical practice”, and handed down shorter sentences to two colleagues who assisted him. The punishments put to rest speculation over whether the Chinese government would bring criminal charges for an act that shocked the world, and are likely to deter others from similar behaviour, say Chinese scientists."